Nucleolar organiser regions in myeloma and benign paraproteinaemia
1990
Nucleolar Organiser Regions in Myeloma and Benign Paraproteinaemia
Sample size: 27
publication
Evidence: low
Author Information
Author(s): R.L. Bryan, R. Janmohamed, J. Crocker, M.J. Leyland
Primary Institution: East Birmingham Hospital
Hypothesis
Can nucleolar organiser region enumeration distinguish between myeloma and benign paraproteinaemia?
Conclusion
AgNOR enumeration is not useful in distinguishing between myeloma and benign paraproteinaemia.
Supporting Evidence
- The mean AgNOR count for multiple myeloma was 8.71.
- The mean count for benign paraproteinaemia was 9.40.
- There was no significant difference between these values.
Takeaway
Doctors tried a special test to tell the difference between two types of blood problems, but it didn't work.
Methodology
Bone marrow aspirates from patients were stained and AgNORs were counted in plasma cells.
Limitations
The study did not find a significant difference in AgNOR counts between the two conditions.
Participant Demographics
17 patients with myeloma and 10 with benign paraproteinaemia.
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