S100A4 Protein in Colon Cancer and Liver Metastases
Author Information
Author(s): Taylor S, Herrington S, Prime W, Rudland P S, Barraclough R
Primary Institution: University of Liverpool
Hypothesis
The presence of S100A4 in carcinoma cells is associated with metastasis and shorter survival in cancer patients.
Conclusion
Higher levels of S100A4 mRNA are found in liver metastases compared to primary colon carcinomas.
Supporting Evidence
- S100A4 mRNA levels were significantly higher in colon carcinomas compared to normal tissues.
- Liver metastases showed even higher levels of S100A4 mRNA than primary colon carcinomas.
- The presence of S100A4 in carcinoma cells is linked to a higher likelihood of metastasis.
Takeaway
This study found that a protein called S100A4 is more common in cancer cells and can help doctors understand how cancer spreads.
Methodology
Quantitative PCR, in situ hybridization, and immunocytochemistry were used to analyze tissue specimens.
Limitations
The study may not account for variability in S100A4 levels due to infiltrating cells.
Participant Demographics
Patients treated at the Royal Liverpool University Hospital between 1993 and 2000.
Statistical Information
P-Value
P=0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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