Retinoic Acid and Prolactin Receptor in Breast Cancer Cells
Author Information
Author(s): Widschwendter M, Widschwendter A, Welte T, Daxenbichler G, Zeimet A G, Bergant A, Berger J, Peyrat J-P, Michel S, Doppler W, Marth C
Primary Institution: Department of Gynecology and Obstetrics, University of Innsbruck
Hypothesis
Retinoids can modulate prolactin receptor expression and its signaling in breast cancer cells.
Conclusion
Retinoids inhibit the expression of prolactin receptor mRNA in breast cancer cells, which may contribute to their anti-tumor effects.
Supporting Evidence
- Retinoids were shown to be potent inhibitors of breast carcinogenesis.
- All-trans- and 9-cis-retinoic acid down-regulated prolactin receptor expression in breast cancer cell lines.
- Maximal effect on prolactin receptor expression was achieved after 24 hours of treatment.
Takeaway
This study found that a substance called retinoic acid can lower the levels of a receptor that helps cancer cells grow, which might help fight breast cancer.
Methodology
The study used Northern blot and quantitative PCR methods to analyze prolactin receptor mRNA expression in breast cancer cell lines treated with retinoids.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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