Role of protease activated receptor-2 in lymph node metastasis of uterine cervical cancers
2008
Role of PAR-2 in Cervical Cancer Spread
Sample size: 30
publication
Evidence: moderate
Author Information
Author(s): Jahan Israt, Fujimoto Jiro, Alam Syed Mahfuzul, Sato Eriko, Tamaya Teruhiko
Primary Institution: Gifu University School of Medicine
Hypothesis
Does PAR-2 play a role in lymph node metastasis of uterine cervical cancers?
Conclusion
PAR-2 might work on lymph node metastasis of uterine cervical cancers and is considered a novel prognostic indicator.
Supporting Evidence
- 12 out of 30 patients showed increased PAR-2 levels in metastatic lymph nodes.
- The 48-month survival rate was 42% for patients with increased PAR-2 levels.
- The survival rate was 82% for patients with unchanged PAR-2 levels.
Takeaway
This study found that higher levels of a protein called PAR-2 in lymph nodes can mean worse outcomes for patients with cervical cancer.
Methodology
Patients underwent surgery, and PAR-2 levels were measured using immunohistochemistry and real-time PCR.
Participant Demographics
Patients aged 28 to 74, with various types of cervical cancer.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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