Effect of the secretory small GTPase Rab27B on breast cancer, growth, invasion, and metastasis
2010
Rab27B as a Marker for Breast Cancer Progression
publication
Evidence: moderate
Author Information
Author(s): An Hendrix, Geert Braems, Marc Bracke, Miguel C. Seabra, Wiliam A. Gahl, Olivier De Wever, Wendy Westbroek
Primary Institution: Ghent University Hospital
Hypothesis
The secretory small GTPase Rab27B may serve as a prognostic marker for breast cancer progression.
Conclusion
Rab27B is a potential key marker for stratification, prognosis, and treatment of early-stage ER-positive breast cancers.
Supporting Evidence
- Rab27B protein levels correlate with lymph node metastasis in ER-positive breast tumors.
- Overexpression of Rab27B in non-invasive ER-positive breast cancer cells stimulates invasive tumor growth.
- Rab27B expression is linked to poor prognosis in breast cancer.
Takeaway
Rab27B helps doctors understand how aggressive a breast cancer is and if it might spread, which can help in deciding the best treatment.
Methodology
The study used cell culture and xenograft mouse models to investigate the role of Rab27B in breast cancer.
Statistical Information
P-Value
0.01
Confidence Interval
1.67 to 60.93
Statistical Significance
p=0.01
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