Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET gene in human squamous cell carcinomas: expression of Δ Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51
2001
Study of p73L and p51 Gene Expression in Skin Cancer
publication
Author Information
Author(s): Senoo M, Tsuchiya I, Matsumura Y, Mori T, Saito Y, Kato H, Okamoto T, Habu S
Primary Institution: Tokai University School of Medicine
Hypothesis
The expression of p73L and p51 isoforms is linked to human squamous cell carcinomas.
Conclusion
The loss of p51 expression and the presence of ΔNp73L may contribute to the development of squamous cell carcinomas.
Supporting Evidence
- A novel isoform, ΔNp73L, was predominantly expressed in squamous cell carcinomas.
- 62% of skin cancer samples lost expression of p51, while it was present in all normal skin samples.
- ΔNp73L expression was found in 75% of p51-expressing skin cancers.
Takeaway
This study found that a new form of a gene called ΔNp73L is often found in skin cancer, while another form, p51, is often missing.
Methodology
The study investigated the expression profiles of p51 and p73L in various human tumor cell lines and primary skin cancer specimens.
Digital Object Identifier (DOI)
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