Inactivation of the von Hippel-Lindau tumour suppressor gene induces Neuromedin U expression in renal cancer cells
2011
VHL Gene Loss Increases Neuromedin U in Kidney Cancer Cells
publication
Evidence: moderate
Author Information
Author(s): Sarah K Harten, Miguel A Esteban, Deepa Shukla, Margaret Ashcroft, Patrick H Maxwell
Primary Institution: University College London
Hypothesis
How does the inactivation of the VHL tumor suppressor gene affect Neuromedin U expression in renal cancer cells?
Conclusion
The study suggests that loss of VHL leads to increased Neuromedin U expression, which may promote kidney cancer progression.
Supporting Evidence
- VHL loss leads to increased NMU expression in renal cancer cells.
- HIF activation mediates the upregulation of NMU in VHL defective cells.
- NMU stimulates migration of renal cancer cells.
Takeaway
When a specific gene that helps control tumors is turned off in kidney cancer cells, another substance called Neuromedin U goes up, which might help the cancer grow.
Methodology
Gene expression microarray and real-time RT-PCR were used to analyze NMU expression in renal cancer cells with and without VHL.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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