Effects of Prone vs. Supine Position on Lung Injury in Sheep
Author Information
Author(s): Nakos George, Batistatou Anna, Galiatsou Eftychia, Konstanti Eleonora, Koulouras Vassilios, Kanavaros Panayotis, Doulis Apostolos, Kitsakos Athanassios, Karachaliou Angeliki, Lekka Marilena E, Bai Maria
Primary Institution: University Hospital of Ioannina, Greece
Hypothesis
Does the position of mechanically ventilated patients affect lung injury and apoptosis in 'end organs'?
Conclusion
The prone position reduces the severity of lung injury and decreases apoptosis in the lung and 'end organs'.
Supporting Evidence
- Lung injury scores were significantly higher in the supine position than in the prone position.
- Apoptotic indices were significantly higher in the supine position across various organs.
- Histological changes were more severe in the supine position, indicating greater lung injury.
Takeaway
Laying on your stomach while on a ventilator helps your lungs work better and keeps your body from getting hurt.
Methodology
Ten sheep were mechanically ventilated for 90 minutes, with five in the supine position and five in the prone position, and lung changes were analyzed histologically.
Limitations
The study had a small sample size and only used one method to confirm apoptosis.
Participant Demographics
Sheep weighing approximately 33 kg.
Statistical Information
P-Value
P < 0.0001
Confidence Interval
-3.9 to -1.82
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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