Cancer Risks Associated with Ampulla of Vater Cancer
Author Information
Author(s): Elizabeth E. Hatch, Rochelle E. Curtis, John D. Boice, Jr., Joseph F. Fraumeni, Jr.
Primary Institution: National Cancer Institute
Hypothesis
Is there an increased risk of second primary cancers among patients with cancer of the ampulla of Vater?
Conclusion
Patients with cancer of the ampulla of Vater have a lower risk of subsequent cancers than previously reported, but there are specific patterns of risk associated with colon and endometrial cancers.
Supporting Evidence
- 34 second cancers were reported compared to 32.5 expected based on SEER registry rates.
- An excess of borderline significance was suggested among patients who survived 5 years or longer.
- An excess risk of secondary AV cancer was observed following colon and endometrial cancers.
Takeaway
If someone has cancer of the ampulla of Vater, they might get other cancers, but not as often as doctors used to think, especially after colon or endometrial cancer.
Methodology
Evaluated patients with ampulla of Vater cancer from population-based cancer registries who survived at least 2 months.
Limitations
Only 14.6% of patients were followed up for 5 years or longer, limiting the number of observed second tumors.
Participant Demographics
51% male and 49% female, with males diagnosed at younger ages.
Statistical Information
P-Value
0.003
Confidence Interval
95% CI 0.73, 1.46
Statistical Significance
p<0.003
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