Hypothesis on the potential role of epigenetic therapy for affecting the chemotherapy resistant phenotype of malignant tumors
2006
Reverting Cancer Drug Resistance with Epigenetic Therapy
publication
Evidence: moderate
Author Information
Author(s): Carlos Perez-Plasencia, Alfonso Duenas-Gonzalez
Primary Institution: Instituto Nacional de Cancerología, Universidad Nacional Autónoma de Mexico
Hypothesis
Can the state of cancer chemotherapy resistance be reverted by epigenetic therapy?
Conclusion
Epigenetic therapy could potentially erase the epigenetic mark associated with chemotherapy resistance and sensitize tumors to treatment.
Supporting Evidence
- Epigenetic changes can occur rapidly after chemotherapy exposure.
- DNA methylation and histone modifications are involved in cancer cell reprogramming.
- Inhibitors of DNA methylation and histone deacetylases are being evaluated in cancer therapy.
Takeaway
This study suggests that changing how genes are turned on and off might help make cancer cells more sensitive to chemotherapy.
Methodology
The study proposes analyzing gene expression data from primary tumors and correlating it with treatment outcomes.
Statistical Information
P-Value
0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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