Dynamics of SARS-CoV-2 Lineages in Children and Adults in Estonia
Author Information
Author(s): Soeorg Hiie, Abroi Aare, Päll Taavi, Dotsenko Liidia, Jaaniso Erik, Kaarna Katrin, Lahesaare Andrio, Naaber Paul, Niglas Heiki, Oopkaup Ott Eric, Peterson Hedi, Reisberg Tuuli, Sadikova Olga, Smit Steven, Talas Ulvi Gerst, Avi Radko, Lutsar Irja, Huik Kristi
Primary Institution: University of Tartu, Estonia
Hypothesis
The study aimed to describe the dynamics of SARS-CoV-2 lineages and genetic diversity in children and adults in Estonia.
Conclusion
SARS-CoV-2 lineages in children and adults were similar, with regional differences and varying similarity to neighboring countries suggesting the importance of mobility in the spread.
Supporting Evidence
- 2,630 sequences from children and 23,031 from adults were included in the study.
- The increase in the proportion of Alpha/Delta/Omicron lineages was delayed in smaller regions.
- Diversity was lower in non-travel-related than travel-related cases until the Delta period.
- Similarity of lineages was delayed compared to Finland during Alpha/Omicron periods.
- Travel-related cases peaked prior to the incidence peaks of Delta and Omicron variants.
Takeaway
The study looked at how COVID-19 variants spread among kids and adults in Estonia, finding that they spread similarly.
Methodology
The study included SARS-CoV-2 sequences from a nationwide study conducted in Estonia, analyzing data from 2021 to 2022 using multinomial logistic regression and linear regression.
Potential Biases
Potential underrepresentation of asymptomatic cases and those not seeking testing.
Limitations
The study used a small proportion of sequenced samples, which may not fully represent the population, and did not include phylogenetic analysis.
Participant Demographics
Children (<15 years) and adults (≥15 years) from various regions in Estonia.
Statistical Information
P-Value
0.02
Confidence Interval
95% CI -1.0…-0.2
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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