Genetics of Obesity: What have we Learned?
2011
Genetics of Obesity: What have we Learned?
publication
Evidence: moderate
Author Information
Author(s): Hélène Choquet, David Meyre
Primary Institution: Ernest Gallo Clinic and Research Center, University of California, San Francisco; McMaster University, Canada
Hypothesis
What have we learned from 15 years of research in the field of genetics and obesity?
Conclusion
The study highlights that genetic factors significantly influence obesity and its interaction with environmental factors.
Supporting Evidence
- Nine loci are involved in Mendelian forms of obesity and 58 loci contribute to polygenic obesity.
- Obesity predisposing genes interact with the environment and influence treatment responses.
- Genetic predisposition to obesity can be mitigated by physical activity.
Takeaway
Scientists have learned a lot about how our genes can make us more likely to be overweight, especially when combined with our environment.
Methodology
The review discusses findings from candidate gene and genome-wide association studies over 15 years.
Limitations
The review is based on existing studies and may not cover all recent findings.
Digital Object Identifier (DOI)
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