Hippocampal Neurogenesis, Depressive Disorders, and Antidepressant Therapy
2007
Hippocampal Neurogenesis, Depressive Disorders, and Antidepressant Therapy
publication
Evidence: moderate
Author Information
Author(s): Eleni Paizanis, Michel Hamon, Laure Lanfumey
Primary Institution: INSERM, U677, Paris, France
Hypothesis
How do stress and antidepressant treatments affect neurogenesis in the hippocampus?
Conclusion
Antidepressant treatments stimulate hippocampal neurogenesis, which may play a role in alleviating depression.
Supporting Evidence
- Stress decreases neurogenesis in the hippocampus.
- Antidepressants increase the proliferation and survival of new neurons.
- Chronic stress can lead to hippocampal atrophy.
- Neurogenesis is involved in learning and memory processes.
- Serotonin plays a critical role in regulating neurogenesis.
Takeaway
The brain can create new cells even in adults, and stress can stop this process, but antidepressants help to make new brain cells again.
Methodology
The review summarizes experimental and clinical data on neurogenesis in relation to stress and antidepressant treatments.
Limitations
The exact mechanisms by which stress and antidepressants affect neurogenesis are not fully understood.
Digital Object Identifier (DOI)
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