Survivin and VEGF as Predictors of Survival in Nasopharyngeal Carcinoma
Author Information
Author(s): Li Yu-Hong, Hu Chun-Fang, Shao Qiong, Huang Ma-Yan, Hou Jing-Hui, Xie Dan, Zeng Yi-Xin, Shao Jian-Yong
Primary Institution: Sun Yat-Sen University Cancer Center
Hypothesis
The expression levels of survivin and VEGF in nasopharyngeal carcinoma tissues are correlated with patient survival outcomes.
Conclusion
Survivin and VEGF over-expression are independent prognostic factors for patients with nasopharyngeal carcinoma.
Supporting Evidence
- Patients with survivin over-expression had a 5-year survival rate of 42.32%, significantly lower than those with low-expression at 70.54%.
- VEGF over-expression was associated with a 5-year survival rate of 40.1%, compared to 67.8% for low-expression.
- Patients with both survivin and VEGF over-expression had a 5-year survival rate of only 18.22%.
Takeaway
This study found that high levels of two proteins, survivin and VEGF, in cancer tissues can help predict how long patients with nasopharyngeal cancer might live.
Methodology
280 cases of nasopharyngeal carcinoma were analyzed for survivin and VEGF expression using immunohistochemistry, and patient survival was tracked.
Potential Biases
Potential bias in patient selection and retrospective data collection.
Limitations
The study is retrospective and relies on archival specimens, which may not represent current treatment outcomes.
Participant Demographics
The cohort included 208 males and 72 females, aged 14 to 86 years, with a median age of 46.
Statistical Information
P-Value
0.0003
Confidence Interval
95% CI, 119.6 ~136.7
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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