Long-term results of intensity-modulated radiotherapy with chemotherapy for hypopharyngeal carcinoma
Author Information
Author(s): Liu Wen-Shan, Hsin Chung-Han, Chou Ying-Hsiang, Liu Jung-Tung, Wu Ming-Fang, Tseng Szu-Wen, Lee Jong-Kang, Tseng Hsien-Chun, Wang Tzu-Hwei, Su Mao-Chang, Lee Huei
Primary Institution: Chung Shan Medical University Hospital
Hypothesis
The study investigates the effectiveness of intensity-modulated radiotherapy combined with chemotherapy for laryngeal preservation in hypopharyngeal carcinoma.
Conclusion
Patients with hypopharyngeal carcinoma treated with IMRT and chemotherapy achieve high rates of functional laryngeal preservation and local-regional control, but late effects like laryngeal stricture are significant.
Supporting Evidence
- The initial complete response rate was 85.2%.
- The laryngeal preservation rate was 63.0%.
- The 5-year overall survival rate was 34.8%.
- 63.0% of patients experienced grade 3 acute dysphagia.
- 18.5% of patients experienced late laryngeal stricture.
Takeaway
This study shows that a special type of radiation therapy combined with medicine can help save the voice box in patients with throat cancer, but some patients may still have problems later.
Methodology
This retrospective study included 27 patients with hypopharyngeal carcinoma who received concurrent chemoradiotherapy and were followed for a median of 53 months.
Potential Biases
Potential biases include selection bias due to the retrospective nature and the specific patient population studied.
Limitations
The study is retrospective and may not account for all variables affecting outcomes.
Participant Demographics
All participants were men with a mean age of 60.7 years, ranging from 42 to 85 years.
Statistical Information
P-Value
0.014
Statistical Significance
p = 0.014
Digital Object Identifier (DOI)
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