BACR MEETING ON ONCOGENES
1988
Workshop on Oncogene Expression in Human Tumours
publication
Author Information
Author(s): N. James, G. Evan, W. Gullick, K. Sikora
Conclusion
The study of oncogene abnormalities has generated interesting associations, but few have direct relevance to clinical medicine.
Supporting Evidence
- The presence of high levels of EGFR is common in squamous cell carcinomas of the lung.
- EGFR status is the best single prognostic indicator in breast cancer.
- Frequent amplification of the c-erbB-2 gene in primary breast carcinomas is associated with elevated protein expression.
- The int-i gene product may function similarly to the wingless gene in cell communication.
- Different carcinogens produce tumours by distinct molecular mechanisms.
Takeaway
Scientists are learning about genes that can cause cancer, but many findings don't yet help doctors treat patients better.
Methodology
The workshop included presentations on various oncogenes and their roles in cancer, with discussions on their implications for treatment.
Limitations
Many findings are not directly applicable to clinical medicine and require further research.
Want to read the original?
Access the complete publication on the publisher's website