Lack of mutation at codon 531 of SRC in advanced colorectal cancers from Italian patients
2001
No SRC Mutation Found in Italian Colorectal Cancer Patients
Sample size: 155
publication
Evidence: high
Author Information
Author(s): Laghi L, Bianchi P, Orbetegli O, Gennari L, Roncalli M, Malesci A
Primary Institution: Istituto Clinico Humanitas
Hypothesis
The genetic activation of src in colon cancer might be restricted to patients belonging to specific ethnic groups.
Conclusion
SRC Gln531AMB does not play a role in the development or progression of colorectal cancer among Italian patients.
Supporting Evidence
- A truncating mutation at codon 531 of c-src was previously identified in North-American patients.
- Two studies failed to confirm SRC 531 mutation in colorectal cancers from North-European and Asiatic patients.
- The study included 155 cases of colorectal cancer with a high prevalence of liver metastasis.
Takeaway
Doctors looked at cancer samples from Italian patients and found no SRC gene mutation, suggesting it might not be a problem for them.
Methodology
A PCR-RFLP assay was used to investigate the occurrence of SRC 531 mutation in primary tumors and metastases.
Participant Demographics
Italian patients with advanced colorectal cancer, high prevalence of liver metastasis (43%).
Digital Object Identifier (DOI)
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