The Role of IL-6 and IL-8 in Ovarian Cancer Prognosis
Author Information
Author(s): Lane Denis, Matte Isabelle, Rancourt Claudine, Piché Alain
Primary Institution: Département de Microbiologie et Infectiologie, Faculté de Médecine, Université de Sherbrooke
Hypothesis
IL-6 and IL-8 levels in ascites may affect the clinical progression of patients with ovarian cancer.
Conclusion
Elevated IL-6, but not IL-8, ascites level is an independent predictor of shorter progression-free survival.
Supporting Evidence
- Mean ascites levels for IL-6 and IL-8 were 6419 pg/ml and 1408 pg/ml respectively.
- High IL-6 ascites levels were significantly correlated with shorter progression-free survival.
- Patients with high levels of IL-6 were 2.3 times more likely to have disease progression.
Takeaway
This study found that high levels of a substance called IL-6 in the fluid around ovarian tumors can mean that patients might not live as long without their cancer getting worse.
Methodology
IL-6 and IL-8 levels were measured in ascites from 39 patients using ELISA, and correlated with clinical parameters and progression-free survival.
Limitations
The small number of patients who received prior chemotherapy limits the generalizability of the findings.
Participant Demographics
Patients were women with newly diagnosed epithelial ovarian cancer.
Statistical Information
P-Value
P = 0.021 for IL-6; P = 0.008 for IL-8; P = 0.033 for multivariate analysis of IL-6.
Confidence Interval
95% CI, 1.09 - 4.84
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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