Genetic Variants in IL-8 and Idiopathic Pulmonary Fibrosis
Author Information
Author(s): Ahn Mi-Hyun, Park Byung-Lae, Lee Shin-Hwa, Park Sung-Woo, Park Jong-Sook, Kim Do-Jin, Jang An-Soo, Park Jai-Soung, Shin Hwa-Kyun, Uh Soo-Taek, Kim Yang-Ki, Kim Young Whan, Han Sung Koo, Jung Ki-Suck, Lee Kye Young, Jeong Sung Hwan, Park Jeong Woong, Choi Byoung Whui, Park In Won, Chung Man Pyo, Shin Hyoung Doo, Song Jin Woo, Kim Dong Soon, Park Choon-Sik, Shim Young-Soo
Primary Institution: Soonchunhyang University Bucheon Hospital
Hypothesis
The study investigates the association of specific SNPs in the IL-8 gene with the risk of developing idiopathic pulmonary fibrosis (IPF).
Conclusion
The common allele of a promoter SNP, rs4073T>A, may increase susceptibility to the development of IPF via up-regulation of IL-8.
Supporting Evidence
- The minor allele frequencies of rs4073T>A and rs2227307T>G were significantly lower in IPF subjects compared to normal controls.
- IL-8 protein concentration in BAL fluids was significantly higher in IPF patients compared to controls.
- Homozygous IPF subjects for the rs4073 T>A common allele exhibited higher IL-8 protein levels than those with the minor allele.
Takeaway
This study found that a specific gene variant might make people more likely to develop a serious lung disease called idiopathic pulmonary fibrosis.
Methodology
The study genotyped SNPs in 237 IPF patients and 456 normal controls, using logistic regression to evaluate associations.
Potential Biases
Potential bias due to the study being conducted in a single population.
Limitations
The study did not validate the findings in an independent population.
Participant Demographics
The study included 237 patients with IPF and 456 normal controls, with similar age and sex ratios.
Statistical Information
P-Value
0.006 for rs4073T>A
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website