Thyroid Hormones and IL-1b in Critically Ill Patients
Author Information
Author(s): Zhenzhou Zhong, Xiaoliu Xiao
Primary Institution: Ganzhou People's Hospital, Department of Emergency, Ganzhou City, JiangXi Province, China
Hypothesis
This study investigates the relationship between serum thyroid hormones and interleukin-1b levels and postmortem tissue deiodinase activity in critically ill patients.
Conclusion
Serum thyroid hormone levels and IL-1b are associated with postmortem deiodinase activity in critically ill patients.
Supporting Evidence
- Serum TSH, T4, and T3 levels were decreased in non-survivors compared to survivors.
- rT3 and IL-1b levels were increased in non-survivors.
- Liver D1 activity was negatively correlated with serum rT3 and IL-1b.
- Liver and skeletal muscle D3 activities were positively correlated with serum rT3 and IL-1b.
Takeaway
Doctors looked at blood from very sick patients to see how thyroid hormones and a protein called IL-1b are connected to how well their bodies work after death.
Methodology
Serum thyroid hormones and IL-1β were measured on the 5th, 15th, and last day of 80 critically ill patients, with liver and skeletal muscle harvested for analysis.
Limitations
The study only explored the effect of one inflammatory factor, IL-1β, and did not investigate the mechanisms by which IL-1β affects deiodinase activity.
Participant Demographics
Patients included 39 with cardiac surgery, 17 with complex surgery, 9 with organ transplantation, 7 with trauma, and 8 with other surgeries.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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