Antibiotic Resistance Patterns in Group B Streptococcus
Author Information
Author(s): Castor Mei L., Whitney Cynthia G., Como-Sabetti Kathryn, Facklam Richard R., Ferrieri Patricia, Bartkus Joanne M., Juni Billie A., Cieslak Paul R., Farley Monica M., Dumas Nellie B., Schrag Stephanie J., Lynfield Ruth
Primary Institution: Minnesota Department of Health
Hypothesis
What are the antibiotic resistance patterns in invasive Group B Streptococcal isolates?
Conclusion
The study found that while Group B Streptococcus remains susceptible to beta-lactams, resistance to clindamycin and erythromycin is increasing.
Supporting Evidence
- All isolates tested were susceptible to penicillin, ampicillin, cefotaxime, and vancomycin.
- Clindamycin resistance was found in 12.7% and erythromycin resistance in 25.6% of isolates.
- Resistance to clindamycin increased from 10.5% in 1996 to 15.0% in 2003.
- Erythromycin resistance increased from 15.8% in 1996 to 32.8% in 2003.
- Serotype V isolates showed higher rates of clindamycin and erythromycin resistance.
Takeaway
This study looked at how well Group B Streptococcus bacteria respond to antibiotics, finding that most are still treatable with certain drugs, but some are becoming resistant.
Methodology
Data on antimicrobial susceptibility, serotype, and epidemiologic data were collected from four states as part of the CDC's Active Bacterial Core surveillance system.
Limitations
Variability in surveillance periods and differences in surveillance populations may affect results.
Participant Demographics
The study included perinatal cases (pregnant and neonatal) and non-pregnant adults across four states.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website