Molecular Epidemiology of MRSA in Rural Alaska
Author Information
Author(s): David Michael Z., Rudolph Karen M., Hennessy Thomas W., Boyle-Vavra Susan, Daum Robert S.
Primary Institution: University of Chicago
Hypothesis
A transition to the dominance of USA300 has occurred in rural southwestern Alaska, similar to that documented elsewhere in the United States.
Conclusion
The epidemiology of MRSA isolates in southwestern Alaska differs significantly from that in the lower 48 states.
Supporting Evidence
- 92% of retrospective collection isolates carried Panton-Valentine leukocidin (PVL) genes.
- All isolates carried staphylococcal chromosomal cassette mec (SCCmec) type IV.
- 57.5% of prospective isolates were clindamycin resistant.
Takeaway
This study looked at MRSA infections in rural Alaska and found that the types of bacteria causing these infections are different from those found in other parts of the U.S.
Methodology
The study involved retrospective and prospective collections of MRSA isolates from outbreaks and hospital surveillance, with genetic testing and antimicrobial susceptibility assessments.
Limitations
The study was limited to one region and the number of isolates in the retrospective collection was not large.
Participant Demographics
Participants were primarily Alaska Natives, with a mix of ages and both sexes represented.
Statistical Information
P-Value
0.47
Statistical Significance
p=0.47
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website