Impact of Treatment on Children with Carbapenem-Resistant Infections
Author Information
Author(s): Avcu Gulhadiye, Erci Ece, Bilen Nimet Melis, Ersayoglu Irem, Ozek Gulcihan, Celtik Ulgen, Terek Demet, Cilli Feriha, Bal Zumrut Sahbudak
Primary Institution: Ege University, Izmir, Turkey
Hypothesis
What are the risk factors and outcomes for children with carbapenem-resistant Enterobacteriaceae bloodstream infections?
Conclusion
The study found a high mortality rate among children with CRE bloodstream infections, with catheter removal significantly lowering mortality rates.
Supporting Evidence
- 14% of the children with CRE-BSIs died within 30 days.
- Previous PICU admission and inotropic support were significant predictors of mortality.
- Removing central venous catheters was associated with lower mortality rates.
Takeaway
This study looked at sick kids with a tough infection and found that taking out their catheters helped them get better.
Methodology
The study analyzed medical records of hospitalized children diagnosed with CRE bloodstream infections from January 2018 to December 2022.
Potential Biases
Potential bias due to the retrospective nature and reliance on medical records.
Limitations
The study is retrospective and conducted at a single center, limiting generalizability.
Participant Demographics
Median age of participants was 11 months, with 66.6% male and all having at least one underlying comorbidity.
Statistical Information
P-Value
0.01
Confidence Interval
95% CI: 1.741–94.137
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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