Impact of Time on Infarct Transmurality in Heart Attack Patients
Author Information
Author(s): de Waha Suzanne, Desch Steffen, Eitel Ingo, Fuernau Georg, Lurz Philipp, Grothoff Matthias, Gutberlet Matthias, Schuler Gerhard, Thiele Holger
Primary Institution: University of Leipzig – Heart Center
Hypothesis
Is there a relationship between the time to reperfusion and the transmurality of infarction in STEMI patients?
Conclusion
Time-to-reperfusion is the only independent predictor for transmural infarction in STEMI patients, but infarct transmurality does not predict death or congestive heart failure.
Supporting Evidence
- Transmural infarction occurred in 50.6% of patients.
- The infarct transmurality score increased with longer ischemic times.
- Time-to-reperfusion was the only independent predictor for transmural infarction.
Takeaway
If heart attack patients get treated faster, it can help reduce the severity of heart damage, but how bad the damage is doesn't affect their chances of dying or having heart failure later.
Methodology
Patients underwent contrast-enhanced MRI and were categorized by time-to-reperfusion, with clinical follow-up after a median of 20 months.
Limitations
Previous studies had small and highly-selected samples, and the relationship between transmural infarction and clinical outcomes was unclear.
Participant Demographics
Patients with ST-elevation myocardial infarction who underwent primary PCI.
Statistical Information
P-Value
p=0.03
Confidence Interval
95%CI 1.01-1.03
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website