Post-Streptococcal Antibodies and Metabolic Syndrome
Author Information
Author(s): Aran Adi, Lin Ling, Finn Laurel Ann, Weiner Karin, Peppard Paul, Young Terry, Mignot Emmanuel
Primary Institution: Stanford University
Hypothesis
Is there an association between post-streptococcal antibodies and metabolic syndrome?
Conclusion
Post-streptococcal anti-PDI antibodies are associated with metabolic syndrome regardless of fasting insulin and CRP levels.
Supporting Evidence
- 308 participants had anti-PDI antibodies, which were significantly associated with metabolic syndrome.
- Participants with anti-PDI antibodies were more likely to meet the diagnostic criteria for metabolic syndrome.
- The association remained significant after adjusting for CRP and fasting insulin.
Takeaway
This study found that certain antibodies related to streptococcal infections might be linked to a condition called metabolic syndrome, which can lead to serious health issues.
Methodology
The study assessed metabolic data and post-streptococcal antibodies in participants from the Wisconsin Sleep Cohort Study.
Potential Biases
Potential response and dropout biases due to the study's design and participant selection.
Limitations
The study may have oversampled individuals with higher prevalence of metabolic syndrome and lacked detailed information on diet and exercise.
Participant Demographics
Mean age 55 years, 45.7% females, 97.1% Caucasians.
Statistical Information
P-Value
0.0062
Confidence Interval
95% CI 1.114, 1.920
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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