Age and HPV Type Affect Clinical Course in Recurrent Respiratory Papillomatosis
Author Information
Author(s): Buchinsky Farrel J., Donfack Joseph, Derkay Craig S., Choi Sukgi S., Conley Stephen F., Myer Charles M. III, McClay John E., Campisi Paolo, Wiatrak Brian J., Sobol Steven E., Schweinfurth John M., Tsuji Domingos H., Hu Fen Z., Rockette Howard E., Ehrlich Garth D., Post J. Christopher
Primary Institution: Allegheny General Hospital, Allegheny-Singer Research Institute, Center for Genomic Sciences, Pittsburgh, Pennsylvania, United States of America
Hypothesis
Does the age of a child and the type of HPV influence the clinical course of recurrent respiratory papillomatosis?
Conclusion
The clinical course of recurrent respiratory papillomatosis is more closely associated with the age of the patient than with the type of HPV they are infected with.
Supporting Evidence
- HPV 11 was found in 40% of the patients studied.
- 81% of the patients had an aggressive clinical course.
- Patients with HPV 11 were diagnosed at a younger age than those with HPV 6.
- The odds of having an aggressive course were 3.9 times higher for HPV 11 compared to HPV 6.
- Age at diagnosis was more closely associated with clinical course than HPV type.
Takeaway
Younger kids with recurrent respiratory papillomatosis tend to have a tougher time than older kids, and having HPV type 11 makes it even harder.
Methodology
The study analyzed papilloma biopsies from 118 patients with juvenile-onset recurrent respiratory papillomatosis, focusing on HPV typing and clinical data.
Potential Biases
The sample may be biased towards more aggressive cases due to the enrollment process.
Limitations
The study may have a biased sample as it primarily included patients with aggressive disease and did not account for all surgical interventions.
Participant Demographics
{"gender":{"male":68,"female":50},"race":{"White":67,"Black":41,"Asian/Other/Not Recorded":10},"age_at_diagnosis":{"median":3.0,"range":"(0.1, 13.1)"}}
Statistical Information
P-Value
0.017
Confidence Interval
95% CI 1.2 to 17
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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