Study of Risk Factors and Antibiotic Resistance in Streptococcal Keratitis
Author Information
Author(s): Cheng Zhen, Shi Qingquan, Peng Bo, Zhang Zijun, Wei Zhenyu, Wang Zhiqun, Zhang Yang, Chen Kexin, Xu Xizhan, Lu Xinxin, Liang Qingfeng, Monchi Mehran, Marasini Sanjay
Primary Institution: Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University
Hypothesis
What are the risk factors, clinical characteristics, and antibiotic susceptibility patterns of Streptococcal keratitis over an 18-year period?
Conclusion
Streptococcal keratitis is a complex ocular infection with multiple risk factors and varying antibiotic resistance patterns among different species.
Supporting Evidence
- S. pneumoniae was the most frequently isolated organism, accounting for 29.8% of cases.
- Main risk factors included previous ocular surface disease (24.6%), ocular surgery (21.4%), and trauma (16.3%).
- Significant differences in clinical characteristics were observed among S. pneumoniae, S. oralis, and S. mitis.
- Resistance rates of aminoglycosides, β-lactams, and fluoroquinolones have increased.
- Poor outcomes correlated with disease duration over one month, central corneal ulcers, and dense infiltrations.
Takeaway
This study looked at eye infections caused by certain bacteria and found that they can be very serious, with different types of bacteria showing different levels of resistance to antibiotics.
Methodology
This retrospective study reviewed data from 350 patients diagnosed with Streptococcal keratitis, analyzing demographics, risk factors, clinical signs, imaging, and antibiotic susceptibility testing.
Limitations
The study is retrospective and may not include all relevant data from follow-up examinations.
Participant Demographics
47.1% of patients were women, with ages ranging from 2 months to 89 years and a mean age of 49.1 years.
Statistical Information
P-Value
p = 0.006
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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