Socioeconomic Inequalities Worsen the Risk of Death in CKD: A Population-Based Cohort Study in Italy
2024

Socioeconomic Inequalities and Death Risk in Chronic Kidney Disease

Sample size: 127457 publication 10 minutes Evidence: high

Author Information

Author(s): Marta Giaccari, Claudia Marino, Pietro Manuel Ferraro, Giulia Cesaroni, Marina Davoli, Nera Agabiti

Primary Institution: Università Cattolica del Sacro Cuore, Rome, Italy

Hypothesis

Disadvantaged socioeconomic position could directly affect the outcomes associated with chronic kidney disease.

Conclusion

Socioeconomic disadvantage is associated with a higher risk of death in patients with chronic kidney disease, but not with the risk of developing end-stage kidney disease.

Supporting Evidence

  • Socioeconomic position is associated with mortality in patients with CKD.
  • Socioeconomic inequalities are stronger in men than in women.
  • There was no evidence of association between deprivation and end-stage kidney disease.

Takeaway

People with less money and resources are more likely to die from kidney disease, but this doesn't mean they will get worse kidney disease than others.

Methodology

The study analyzed a cohort of incident CKD cases from health information systems in Italy, using Cox proportional hazard models to assess the association between socioeconomic deprivation and outcomes.

Potential Biases

Potential bias due to the algorithm used for case identification and the exclusion of patients without deprivation index information.

Limitations

The study used a validated algorithm for identifying CKD cases that may not fully capture incident cases, and missing deprivation index data for some patients could affect results.

Participant Demographics

The cohort included 127,457 patients, with 55.9% men and an average age of 73 years.

Statistical Information

P-Value

0.02

Confidence Interval

1.12 to 1.21

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.34067/KID.0000000592

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