Effect of Methylprednisolone Injection on Diabetic Macular Edema
Author Information
Author(s): Javadzadeh Alireza
Primary Institution: Tabriz University of Medical Sciences
Hypothesis
To investigate the efficacy of posterior subtenon methylprednisolone acetate injection in treatment of refractory diffuse clinically significant diabetic macular edema (CSME).
Conclusion
Posterior subtenon methylprednisolone acetate may improve early visual outcome in diffuse diabetic macular edema that fails to respond to conventional laser photocoagulation.
Supporting Evidence
- Mean baseline visual acuity improved significantly from 0.8 to 0.6 at 3 months.
- Mean foveal thickness decreased from 388 μm at baseline to 231 μm after 3 months.
- Visual acuity improvement was significant in eyes with extrafoveal hard exudates.
Takeaway
This study looked at how a special injection can help people with a serious eye problem caused by diabetes. It found that the injection can help improve vision.
Methodology
A prospective, nonrandomized, interventional case series involving 52 eyes diagnosed with CSME treated with posterior subtenon injection of methylprednisolone acetate after laser therapy.
Limitations
The study's long-term effects of treatment are not clear and further studies are needed.
Participant Demographics
Mean age of participants was 55 years, with 48% males and 52% females.
Statistical Information
P-Value
0.003
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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