Hepatocyte growth factor modulates motility and invasiveness of ovarian carcinomas via Ras-mediated pathway
2000
Hepatocyte Growth Factor and Ovarian Cancer
publication
Author Information
Author(s): Ueoka Y, Kato K, Kuriaki Y, Horiuchi S, Terao Y, Nishida J, Ueno H, Wake N
Primary Institution: Department of Reproductive Physiology and Endocrinology, Medical Institute of Bioregulation, Kyushu University
Hypothesis
Hepatocyte growth factor (HGF) induces migration and invasion of ovarian cancer cells via a Ras-mediated pathway.
Conclusion
The study found that HGF promotes the motility and invasiveness of ovarian cancer cells through specific signaling pathways.
Supporting Evidence
- HGF induces migration and invasion of ovarian cancer cells.
- HGF stimulates autophosphorylation of its receptor.
- Activation of the Ras-MAP kinase cascade is involved in HGF's effects.
- Infection with Ras dominant-negative adenovirus reduced HGF-induced activities.
- Both MEK and PI3-kinase pathways are involved in HGF-stimulated invasiveness.
Takeaway
Hepatocyte growth factor helps ovarian cancer cells move and spread, which is important for how the cancer grows.
Methodology
The study involved demonstrating the effects of HGF on ovarian cancer cells and the signaling pathways activated.
Digital Object Identifier (DOI)
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