Neuronal and Microglial Mechanisms of Neuropathic Pain
Author Information
Author(s): Zhuo Min, Wu Gongxiong, Wu Long-Jun
Primary Institution: Center for Neuron and Disease, Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, China; Department of Physiology, Faculty of Medicine, University of Toronto; Research Division, Joslin Diabetes Center, Harvard Medical School
Hypothesis
Activity-dependent neuronal plasticity is a key target for treatment in neuropathic pain.
Conclusion
The study highlights the importance of both neuronal and microglial mechanisms in the development and maintenance of neuropathic pain.
Supporting Evidence
- Neuropathic pain is a chronic pain state resulting from nerve injury.
- Current treatments for neuropathic pain often show limited efficacy.
- Glial cells like microglia play a significant role in modulating pain transmission.
Takeaway
This study explains how nerve injuries can cause long-lasting pain by changing how nerve cells and support cells in the brain communicate.
Methodology
The review compares recent progress in understanding neuronal and glial mechanisms underlying neuropathic and inflammatory pain.
Limitations
The review is based on existing literature and may not cover all recent findings.
Digital Object Identifier (DOI)
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