Toxicities of the antifolate, CB3717
Toxicities of the antifolate, CB3717
Sample size: 26
Commentary
Author Information
Author(s): Calvert, A.H., Alison, D.L., Harland, S.J.
Primary Institution: The Institute of Cancer Research
Conclusion
The study found that ALT levels diminished on repeated dosage only at the fourth course of treatment, and prednisolone did not affect ALT levels in most patients.
Supporting Evidence
- ALT levels diminished on repeated dosage at the fourth course of treatment.
- Prednisolone administration did not affect ALT levels in 23 patients.
Takeaway
This study looked at how a drug affected liver enzymes in cancer patients, and it found that the drug didn't help much after several doses.
Methodology
The study involved administering the drug to patients and measuring liver enzyme levels.
Limitations
The study did not report on AST levels and had a small sample size for repeated courses.
Participant Demographics
Patients with colorectal cancer.
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