Prolactin Receptor and Breast Cancer Study
Author Information
Author(s): S. De Placidol, C. Gallo, F. Perrone, A. Marinelli, C. Pagliarulo, C. Carlomagno, G. Petrella, M. D'Istria, G. Delrio, A.R. Bianco
Primary Institution: University of Naples, Medical School II
Hypothesis
Does the prolactin receptor correlate with estrogen and progesterone receptors in primary breast cancer and have prognostic significance?
Conclusion
The study found no significant correlation between prolactin receptors and estrogen or progesterone receptors, nor did it find any independent prognostic role for prolactin receptors in disease-free survival.
Supporting Evidence
- PRLR was positive in 75 out of 229 patients (32.8%).
- No significant correlation was found between PRLR and either ER or PgR.
- The study showed no evidence of an independent prognostic role of PRLR on disease-free survival.
Takeaway
This study looked at whether a hormone receptor called prolactin receptor is related to other hormone receptors in breast cancer, and it found that it isn't really connected.
Methodology
The study involved a randomized clinical trial where patients received either Tamoxifen or no therapy, and various hormone receptors were assayed from tumor samples.
Limitations
The study did not analyze overall survival due to a limited number of events.
Participant Demographics
The study included 308 pre- and post-menopausal women with early breast cancer, aged less than 80.
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