Study on Ki-67 and Outcomes in Cats with Nasal Adenocarcinoma Treated with Radiotherapy
Author Information
Author(s): Aonta Premkamon, Jaiyangyeun Piraya, Theerapan Wutthiwong, Srisampan Supreeya, Wongsali Charuwan, Kovitvadhi Attawit, Jaroensong Tassanee
Primary Institution: Kasetsart University, Faculty of Veterinary Medicine
Hypothesis
What is the prognostic significance of Ki-67 expression in feline nasal adenocarcinoma treated with hypofractionated radiotherapy?
Conclusion
Cats with high Ki-67 levels had significantly longer survival times than those with lower levels.
Supporting Evidence
- Cats with a favorable response to treatment had significantly longer survival times than those with a poor response.
- Cats with high Ki-67 expression had significantly longer survival times than those with lower Ki-67 levels.
- Median survival time for all cats was 550 days, with a range of 56 to 1118 days.
Takeaway
This study looked at cats with a type of nose cancer and found that those with higher levels of a specific protein (Ki-67) lived longer after treatment.
Methodology
The study involved 19 cats with nasal adenocarcinoma treated with hypofractionated radiotherapy, assessing Ki-67 expression and clinical outcomes.
Potential Biases
Potential bias due to the retrospective nature and incomplete data.
Limitations
The study was retrospective with a small sample size and incomplete follow-up data for some cats.
Participant Demographics
Cats aged 2-17 years, predominantly domestic shorthair, with a median age of 10 years.
Statistical Information
P-Value
p = 0.028
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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