NADPH oxidase as a therapeutic target in Alzheimer's disease
2008
NADPH Oxidase as a Target for Alzheimer's Disease Treatment
publication
Evidence: moderate
Author Information
Author(s): Michelle L Block
Primary Institution: Virginia Commonwealth University Medical Campus
Hypothesis
Targeting NADPH oxidase can reduce neurotoxic factors and inhibit neuronal damage in Alzheimer's disease.
Conclusion
Targeting NADPH oxidase may help halt the progression of Alzheimer's disease by reducing neurotoxic factors produced by microglia.
Supporting Evidence
- NADPH oxidase is upregulated in Alzheimer's disease and contributes to neurotoxicity.
- Microglial activation leads to the production of neurotoxic factors in response to amyloid-beta.
- Targeting NADPH oxidase may inhibit the production of pro-inflammatory cytokines.
Takeaway
Scientists think that by stopping a certain enzyme called NADPH oxidase, they can help protect brain cells in people with Alzheimer's disease.
Digital Object Identifier (DOI)
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