Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Down-Regulates IL-22R1 Expression through a Cis-Acting Element within the Promoter Region
2011
KSHV LANA Down-Regulates IL-22R1 Expression
publication
Evidence: moderate
Author Information
Author(s): Su Ling Liao, Qingjiao Wu, Yang Chen, Xulin
Primary Institution: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China
Hypothesis
Can KSHV LANA regulate IL-22R1 expression through direct binding to its promoter?
Conclusion
The study found that KSHV LANA down-regulates IL-22R1 expression by binding to a specific element in the IL-22R1 promoter.
Supporting Evidence
- KSHV LANA was shown to down-regulate IL-22R1 expression via direct binding to the LBS located within the IL-22R1 promoter region.
- KSHV-positive cells exhibited impaired responses to IL-22 stimulation.
- A total of 2980 genes were significantly up- or down-regulated in the KS tissue compared to normal tissue.
Takeaway
This study shows that a virus can change how our body responds to certain signals by affecting a specific receptor, which might help the virus survive.
Methodology
The researchers used cDNA microarray analysis and luciferase reporter assays to study gene expression and regulation.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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