No SMAD4 hypermethylation in colorectal cancer
2000
No SMAD4 Hypermethylation in Colorectal Cancer
Sample size: 42
publication
Author Information
Author(s): Roth S, Laiho P, Salovaara R, Launonen V, Aaltonen L A
Primary Institution: University of Helsinki, Finland
Hypothesis
Does promoter hypermethylation play a role in SMAD4 inactivation in colorectal cancer?
Conclusion
The study found that hypermethylation of the SMAD4 promoter region is not a frequent event in colorectal tumorigenesis.
Supporting Evidence
- The chromosome region 18q21 is frequently deleted in colorectal cancers.
- Three candidate tumour suppressor genes, DCC, SMAD4 and SMAD2, map to this region.
- Somatic SMAD4 mutations have been detected in some colorectal carcinomas.
Takeaway
The researchers looked at cancer samples to see if a specific change in a gene called SMAD4 was common in colorectal cancer, but they found it wasn't.
Methodology
Methylation analysis was performed on 42 colorectal tumors.
Digital Object Identifier (DOI)
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