Differential effect of vinorelbine versus paclitaxel on ERK2 kinase activity during apoptosis in MCF-7 cells
2001
Effects of Vinorelbine and Paclitaxel on ERK2 Activity in Cancer Cells
publication
Author Information
Author(s): Liu X M, Wang L G, Kreis W, Budman D R, Adams L M
Primary Institution: North Shore University Hospital, NYU School of Medicine
Hypothesis
The study evaluates the differential effects of vinorelbine and paclitaxel on ERK2 kinase activity and its role in apoptosis in MCF-7 cells.
Conclusion
Vinorelbine activates ERK2 and induces apoptosis through bcl-2 phosphorylation, while paclitaxel inhibits ERK2 activity.
Supporting Evidence
- Vinorelbine rapidly activates ERK2 kinase activity.
- Paclitaxel significantly decreases ERK2 kinase activity.
- Vinorelbine induces bcl-2 phosphorylation and apoptosis.
- PARP cleavage occurs quickly after treatment with vinorelbine or paclitaxel.
Takeaway
This study shows that vinorelbine helps cancer cells die by changing certain proteins, while paclitaxel does the opposite.
Methodology
The study evaluated ERK2 activity and its role in apoptosis in MCF-7 cells treated with vinorelbine and paclitaxel.
Digital Object Identifier (DOI)
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