Comparing Mitomycin C Treatments for Pterygium Surgery
Author Information
Author(s): Ehab M. Ghoneim, Ahmed A. Gab-Allah, Amro A. Kamal, Mohamed Z.
Primary Institution: Suez Canal University
Hypothesis
Is preoperative local injection of mitomycin C more effective than intraoperative application in preventing pterygium recurrence after surgery?
Conclusion
Preoperative local injection of mitomycin C is as effective as intraoperative topical application for preventing pterygium recurrence after surgical removal.
Supporting Evidence
- The recurrence rate was 5.7% in the preoperative group and 8.57% in the intraoperative group at 1 year postoperatively.
- Both methods had similar success rates, with no serious complications reported.
- Mild complications included conjunctival irritation and subconjunctival hemorrhage, which resolved within weeks.
Takeaway
Doctors tested two ways to use a medicine called mitomycin C to stop pterygium from coming back after surgery, and found both ways worked equally well.
Methodology
70 patients with primary pterygia were randomly assigned to receive either preoperative subconjunctival injection or intraoperative application of mitomycin C, followed by surgical removal of pterygium.
Limitations
No control group without mitomycin C was included due to high recurrence rates.
Participant Demographics
Mean age was 33.0 years for Group A and 34.0 years for Group B, with a mix of male and female participants.
Statistical Information
P-Value
0.99
Statistical Significance
p>0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website