Persistent Organic Pollutants and Periodontal Disease
Author Information
Author(s): Lee Duk-Hee, Jacobs David R. Jr., Kocher Thomas
Primary Institution: Kyungpook National University
Hypothesis
There is an association between serum concentrations of persistent organic pollutants (POPs) and the prevalence of periodontal disease.
Conclusion
POPs, especially organochlorine pesticides, were positively associated with periodontal disease, possibly through immunomodulation.
Supporting Evidence
- Organochlorine pesticides were most strongly associated with periodontal disease.
- Participants with periodontal disease had higher white blood cell counts, but neutrophil counts were inversely related to OC pesticides.
- Adjusted odds ratios for OC pesticides showed a clear trend in association with periodontal disease.
Takeaway
This study found that certain harmful chemicals in our bodies can make gum disease more likely.
Methodology
Cross-sectional analysis of serum POP concentrations and periodontal disease prevalence using data from the National Health and Nutrition Examination Survey 1999–2002.
Potential Biases
Potential misclassification bias and residual confounding due to unknown lifestyle factors.
Limitations
The cross-sectional design does not allow for causal inferences, and there may be misclassification bias and residual confounding.
Participant Demographics
45.5% men, 45.4% white, 16.5% current smokers, mean age 45.5 years.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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