Cognitive Connectome Changes in Dementia with Lewy Bodies
Author Information
Author(s): Yanez-Perez Roraima, Garcia-Cabello Eloy, Habich Annegret, Cedres Nira, Diaz-Galvan Patricia, Abdelnour Carla, Toledo Jon B., Barroso José, Ferreira Daniel
Primary Institution: Karolinska Institutet, Stockholm, Sweden
Hypothesis
We hypothesized prominent alterations in the cognitive connectome of DLB patients in comparison with HC, particularly involving attention, executive, and visual domains.
Conclusion
The cognitive connectome of DLB patients shows a loss of segregation, leading to a loss of cognitive specialization.
Supporting Evidence
- DLB patients showed significantly lower performance in all cognitive domains compared with healthy controls.
- DLB had more years of education than AD.
- DLB patients had a higher global efficiency and lower transitivity than healthy controls.
Takeaway
This study looked at how the brain connections of people with dementia with Lewy bodies are different from healthy people and those with Alzheimer's, showing that their brain connections are less specialized.
Methodology
We built cognitive connectomes for DLB, healthy controls, and AD using correlations among 24 cognitive measures and compared them using global and nodal graph measures.
Potential Biases
Diagnosis of DLB was entirely clinical, while the underlying Lewy body-related pathology can only be confirmed post-mortem.
Limitations
The availability of data was not even across cognitive measures, which may have led to the underrepresentation of some cognitive domains.
Participant Demographics
DLB group had 86% men and an average age of 71.9 years with 16.3 years of education.
Statistical Information
P-Value
p<0.001
Confidence Interval
95%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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