Effects of Botulinum Toxin on Muscle Tone in Children with Congenital Zika Syndrome
Author Information
Author(s): Silva Patrícia Juliana da, Brito Ana Stela Salvino de, Silva Mariana Balbino da, Barros Nathalia Nogueira Romariz, Tavares Jousilene Sales, Gama Gabriela Lopes
Primary Institution: Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ)
Hypothesis
To evaluate the effects of the botulinum toxin (BTX-A) on muscle tone and joint mobility in children with congenital Zika syndrome (CZS).
Conclusion
The use of BTX-A can reduce hypertonia in CZS children, with no impact on joint mobility.
Supporting Evidence
- After BTX-A application, a bilateral reduction in hypertonia was observed in elbow flexor and hip abductor muscles.
- Caregivers reported no adverse effects after the application.
- Children were evaluated before and after the treatment to assess changes in muscle tone.
Takeaway
This study found that botulinum toxin can help kids with Zika syndrome feel less tight in their muscles, but it doesn't help them move their joints better.
Methodology
This was a longitudinal case series conducted at a Support Center for Children with Microcephaly, collecting data from medical records before and after BTX-A application.
Potential Biases
Potential bias due to nonprobabilistic sampling and reliance on medical records.
Limitations
The small sample size and short follow-up period may limit the generalizability of the findings.
Participant Demographics
13 children (9 boys) with a mean age of 77 ± 7.1 months, 7 had microcephaly at birth.
Statistical Information
P-Value
p<0.01 for elbow flexors, p<0.05 for hip abductors.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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