Resting-state fMRI for Seizure Onset Localization
Author Information
Author(s): Boerwinkle Varina L., Nowlen Mary A., Vazquez Jesus E., Arhin Martin A., Reuther William R., Cediel Emilio G., McCarty Patrick J., Manjón Iliana, Jubran Jubran H., Guest Ashley C., Gillette Kirsten D., Nowlen Frances M., Pines Andrew R., Kazemi Meitra H., Qaqish Bahjat F.
Primary Institution: University of North Carolina, School of Medicine
Hypothesis
Resting-state functional MRI (rs-fMRI) may localize the seizure onset zone (SOZ) for epilepsy surgery, when compared to intracranial EEG and surgical outcomes.
Conclusion
The study found that rs-fMRI has high sensitivity but low specificity in localizing the seizure onset zone compared to other modalities.
Supporting Evidence
- 9,550 articles were screened, and 25 met inclusion criteria.
- High sensitivity (0.91) and low specificity (0.09) were found for rs-fMRI.
- Significant heterogeneity in agreement odds ratios was observed across studies.
Takeaway
This study looked at how well resting-state fMRI can find where seizures start in the brain, and it found that while it can be good at finding them, it sometimes makes mistakes.
Methodology
A systematic review and meta-analysis of studies comparing rs-fMRI to other seizure localization methods.
Potential Biases
Some studies had high or uncertain risk of bias in patient selection and reference tests.
Limitations
The study included many small studies, which may limit the reliability of the findings.
Participant Demographics
Participants included both adults and children with drug-resistant epilepsy.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI: 4.31 to 14.90
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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