Increase of Genetic Diversity in Plasmodium vivax in South Korea
Author Information
Author(s): Honma Hajime, Kim Jung-Yeon, Palacpac Nirianne MQ, Mita Toshihiro, Lee Wonja, Horii Toshihiro, Tanabe Kazuyuki
Primary Institution: Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University
Hypothesis
What is the genetic diversity and population structure of Plasmodium vivax in South Korea?
Conclusion
The study found a significant increase in genetic diversity of Plasmodium vivax in South Korea from 1997-2000 to 2007.
Supporting Evidence
- Mean expected heterozygosity increased from 0.382 in 1997-2000 to 0.545 in 2007.
- The number of multilocus genotypes increased from 7 in 1997-2000 to 27 in 2007.
- Genotype diversity was statistically significant at 0.661 in 1997-2000 and 0.995 in 2007.
Takeaway
Scientists studied the malaria parasite in South Korea and found that it has become more diverse recently, which could make it harder to control.
Methodology
The study analyzed microsatellite polymorphism from 58 P. vivax isolates collected during two periods: 1997-2000 and 2007.
Limitations
The sample size is relatively small compared to other geographic areas.
Participant Demographics
Isolates were collected from indigenous P. vivax-infected patients near the DMZ in South Korea.
Statistical Information
P-Value
0.023
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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