Effects of Vitex grandifolia Leaf Extract on Rats
Author Information
Author(s): Mbang Owolabi, Abass Moyosola M., Emeka Promise M., Jaja Smith I., Nnoli Martin, Dosa Benjamin O. S.
Primary Institution: University of Lagos, Lagos, Nigeria
Hypothesis
The study investigates the toxicity and biochemical effects of prolonged administration of Vitex grandifolia leaf extract in rats.
Conclusion
Prolonged administration of the aqueous leaf extract of Vitex grandifolia tends to be toxic to rats, affecting their liver, kidney, and overall health.
Supporting Evidence
- The extract caused significant increases in serum electrolytes and liver function enzymes.
- Histopathological alterations were observed in the liver, kidney, and lungs of treated rats.
- The treated rats exhibited major clinical signs such as increased thirst and urination.
Takeaway
Giving rats a plant extract for a long time made them sick and lose weight, showing that the plant can be harmful.
Methodology
Rats were given different doses of the leaf extract for 14 days, and their liver and kidney functions, blood chemistry, and organ histopathology were examined.
Limitations
The study did not determine the LD50 due to no mortality observed at high doses.
Participant Demographics
Sprague-Dawley albino rats of either sex weighing between 220 and 230 g.
Statistical Information
P-Value
p≤0.001
Statistical Significance
p≤0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website