Cadherin-9 as a Marker for Renal Fibroblasts
Author Information
Author(s): Thedieck Cornelia, Kalbacher Hubert, Kuczyk Markus, Müller Gerhard A., Müller Claudia A., Klein Gerd
Primary Institution: University Medical Clinic, Tübingen, Germany
Hypothesis
Cadherin-9 is a specific and reliable marker for renal fibroblasts in healthy and diseased kidneys.
Conclusion
Cadherin-9 is a novel and reliable cell surface marker for fibroblasts in healthy and diseased kidneys.
Supporting Evidence
- Cadherin-9 was found to be exclusively expressed by renal fibroblasts.
- The percentage of cadherin-9-positive cells was three to five times higher in fibrotic kidneys compared to healthy kidneys.
- Cadherin-9 expression was induced in renal epithelial cells undergoing epithelial-mesenchymal transition.
Takeaway
Cadherin-9 helps scientists identify different types of kidney cells, especially those involved in kidney health and disease.
Methodology
The study analyzed cadherin-9 expression in human renal cell lines and tissues using RT-PCR and immunohistochemistry.
Limitations
The study primarily focused on human tissues and may not be applicable to other species.
Statistical Information
P-Value
p<0.00001
Statistical Significance
p<0.00001
Digital Object Identifier (DOI)
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