Carboxymethyl hemicellulose hydrogel as a fluorescent biosensor for bacterial and fungal detection with DFT and molecular docking studies
2025
Fluorescent Hydrogel for Detecting Bacteria and Fungi
publication
Evidence: high
Author Information
Author(s): Tohamy Hebat-Allah S.
Primary Institution: National Research Centre, Egypt
Hypothesis
Can a carboxymethyl hemicellulose hydrogel with nitrogen-doped carbon dots effectively detect bacterial and fungal contaminants?
Conclusion
The CM-Hemi@Ca-N–CDs hydrogel shows strong antibacterial and antifungal properties, making it effective for microbial detection.
Supporting Evidence
- The hydrogel effectively inhibited both Gram-negative and Gram-positive bacteria.
- Molecular docking studies showed strong binding interactions with bacterial and fungal proteins.
- Fluorescence microscopy revealed different light emissions when interacting with various microorganisms.
Takeaway
This study created a special jelly that can glow and help find bad germs in food, making it safer to eat.
Methodology
The hydrogel was made by combining carboxymethyl hemicellulose and nitrogen-doped carbon dots, then tested for antibacterial and antifungal activity.
Digital Object Identifier (DOI)
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