Breast Cancer Risk in Mothers of Children with Soft Tissue Sarcomas
Author Information
Author(s): J.M. Birch, A.L. Hartley, H.B. Marsden, M. Harris, R. Swindell
Primary Institution: Manchester Children's Tumour Registry
Hypothesis
Is there an increased risk of developing cancer among the mothers of children with soft tissue sarcomas?
Conclusion
Mothers of children with soft tissue sarcomas have a significantly increased risk of developing breast cancer, especially in certain sub-groups.
Supporting Evidence
- There were 6 cases of breast cancer among the mothers, all pre-menopausal.
- The overall risk to the mothers was 3-fold compared to the general population.
- The highest excess risk was found in mothers of boys with pelvic tumors.
- Histological review confirmed the types of breast cancer present in the mothers.
Takeaway
Moms of kids with a specific type of cancer are more likely to get breast cancer themselves, especially if their child is younger or has certain types of tumors.
Methodology
The study reviewed health status and cause of death in mothers of children diagnosed with soft tissue sarcomas from a population-based registry.
Potential Biases
Potential bias in the selection of cases and reliance on medical records for health status.
Limitations
The study may not account for all potential confounding factors and relies on historical data.
Participant Demographics
Mothers of children with soft tissue sarcomas, median age at last follow-up was 44 years.
Statistical Information
P-Value
0.01
Statistical Significance
p=0.01
Want to read the original?
Access the complete publication on the publisher's website