Genetic Variants Linked to Diseases in Asian Indians

Sample size: 576 publication Evidence: moderate

Author Information

Author(s): Pemberton Trevor J, Mehta Niyati U, Witonsky David, Di Rienzo Anna, Allayee Hooman, Conti David V, Patel Pragna I

Primary Institution: Institute for Genetic Medicine, Keck School of Medicine, University of Southern California

Asian Indians have a distinct genetic profile that influences the prevalence of common diseases.

The study highlights the unique genetic characteristics of the Indian population that may contribute to the prevalence of certain diseases.

The study found that allele frequency differences between Indian language groups were small.
A latitudinal cline was identified for allele frequencies of SNPs associated with hypertension and taste perception.
The results support the inclusion of the Indian population in genetic studies due to their unique genotype and phenotype characteristics.

This study looked at how certain genes related to diseases are found in people from India, showing that they have unique genetic traits.

The study analyzed 1200 genome-wide polymorphisms in a cohort of 576 India-born Asian Indians sampled in the United States.

The study may be biased towards higher caste individuals due to the sampling of first-generation immigrants in the U.S.

The cohort may not represent a random sample from India, and the small sample sizes for some language groups limit the findings.

Participants were India-born Asian Indians living in the U.S., representing 15 language groups.

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