Oxidative Stress and Cardiac Damage in Diabetic Rats
Author Information
Author(s): Dallak Mohammad M, Mikhailidis Dimitri P, Haidara Mohamed A, Bin-Jaliah Ismaeel M, Tork Olaa M, Rateb Moshira A, Yassin Hanaa Z, Al-refaie Zeinb A, Ibrahim Ibrahim M, Elawa Samy M, Rashed Laila A, Afifi Noha A
Primary Institution: Faculty of Medicine, Cairo University
Hypothesis
To investigate the possible role of oxidative stress as a common mediator of apoptosis and cardiac damage in diabetes.
Conclusion
Administration of both vitamin E and insulin was effective in reducing markers of oxidative stress and apoptosis and improving parameters of cardiac function in experimental animals.
Supporting Evidence
- Markers of oxidative stress and apoptosis were significantly decreased in rats treated with both insulin and vitamin E.
- Diabetes induced significant increases in serum CK activity in untreated diabetic rats.
- Treatment with vitamin E and insulin decreased CK activity back to control levels.
Takeaway
This study found that giving diabetic rats vitamin E and insulin together helped protect their hearts from damage.
Methodology
The study involved 50 male Wistar rats divided into 5 groups, with diabetes induced in all but the control group, and treatments administered for 4 weeks.
Participant Demographics
50 male albino rats, weighing 170-200 g.
Statistical Information
P-Value
p<0.001 for CK activity increase in untreated diabetic group.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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